Just about anything is possible for a 1964-72 GM A-body. Just don't ask Buick owners for advice on fitting a Chevy engine in your car. Interiors and other parts show up on eBay all the time.
The info you want has been discussed many times on this board, and on wwww.v8buick.com, and on www.buickclub.org. Also, the Buick Performance Group on groups.yahoo.com has many posts about such modifications
You are looking at a lot of work. Many people are happy keeping the 300 engine and some mods.
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